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International Breastfeeding Journal
Review Open Access
A new paradigm for depression in new mothers: the central role of
inflammation and how breastfeeding and anti-inflammatory
treatments protect maternal mental health
Kathleen Kendall-Tackett*
Address: Family Research Laboratory, 126 Horton Social Science Center, 20 College Road, University of New Hampshire, Durham, New
Hampshire, 03824, USA
Email: Kathleen Kendall-Tackett* – kkendallt@aol.com
* Corresponding author
Abstract
Background: Research in the field of psychoneuroimmunology (PNI) has revealed that depression
is associated with inflammation manifested by increased levels of proinflammatory cytokines.
Discussion: The old paradigm described inflammation as simply one of many risk factors for
depression. The new paradigm is based on more recent research that has indicated that physical
and psychological stressors increase inflammation. These recent studies constitute an important
shift in the depression paradigm: inflammation is not simply a risk factor; it is the risk factor that
underlies all the others. Moreover, inflammation explains why psychosocial, behavioral and physical
risk factors increase the risk of depression. This is true for depression in general and for
postpartum depression in particular. Puerperal women are especially vulnerable to these effects
because their levels of proinflammatory cytokines significantly increase during the last trimester of
pregnancy – a time when they are also at high risk for depression. Moreover, common experiences
of new motherhood, such as sleep disturbance, postpartum pain, and past or current psychological
trauma, act as stressors that cause proinflammatory cytokine levels to rise. Breastfeeding has a
protective effect on maternal mental health because it attenuates stress and modulates the
inflammatory response. However, breastfeeding difficulties, such as nipple pain, can increase the
risk of depression and must be addressed promptly.
Conclusion: PNI research suggests two goals for the prevention and treatment of postpartum
depression: reducing maternal stress and reducing inflammation. Breastfeeding and exercise reduce
maternal stress and are protective of maternal mood. In addition, most current treatments for
depression are anti-inflammatory. These include long-chain omega-3 fatty acids, cognitive therapy,
St. John’s wort, and conventional antidepressants.